General Information:

Id: 3,778 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
BTO:0001103 skeletal muscle, BTO:0001563 vastus lateralis
Reference: Sparks LM et al.(2005) A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle Diabetes 54: 1926-1933 [PMID: 15983191]

Interaction Information:

Comment Because expression levels of genes involved in the function of mitochondria decreased, the expression of genes known to be involved in mitochondrial biogenesis was examined. Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1) alpha and PGC1beta mRNA were decreased by -20% and -25%, respectively. Mitochondrial transcription factor A (TFAM), a key activator of mitochondrial transcription and its genome replication, was not significantly changed, nor was nuclear respiratory factor 1 (NRF1).
Formal Description
Interaction-ID: 36977


high-fat diet

decreases_expression of



in skeletal muscle