General Information:

Id: 368 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
ob/+ mouse, ob/ob mouse
Reference: Kammoun HL et al.(2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice J. Clin. Invest. 5: 1201-1215 [PMID: 19363290]

Interaction Information:

Comment Akt/PKB phosphorylation on both Thr308 and Ser473, which was strongly reduced in ob/ob mice compared with ob/+ mice, was upregulated by ER stress inhibition in ob/ob mice, whereas there were no marked effects of GRP78 overexpression in ob/+ mice.
Formal Description
Interaction-ID: 1511

organism model

ob/ob mouse

affects_activity of



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