General Information:

Id: 357 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000138 midbrain
Reference: McCoy MK et al.(2006) Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinsons disease. J. Neurosci. 26: 9365-9375 [PMID: 16971520]

Interaction Information:

Comment Blocking soluble TNF signaling with experimental TNF inhibitor called XENP345 in vivo, provides neuroprotection to dopamine neurons from 6-OHDA-induced death.
Formal Description
Interaction-ID: 1422

increases_activity of


neuron death