General Information:

Id: 353 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Rattus norvegicus
BTO:0000138 midbrain
Reference: Hartmann A et al.(2001) Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinsons disease, but pathway inhibition results in neuronal necrosis. J. Neurosci. 21: 2247-2255 [PMID: 11264300]

Interaction Information:

Comment Primary dopaminergic cell cultures treated with MPP(+) are not protected by caspase 8 inhibitors like Z-IE(OMe)TD(OMe)-FMK.
Formal Description
Interaction-ID: 1401

drug/chemical compound

Caspase 8 inhibitor

NOT decreases_activity of


neuron death