General Information:

Id: 341 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
ob/ob mouse
Reference: Lin HZ et al.(2000) Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat. Med. 6: 998-1003 [PMID: 10973319]

Interaction Information:

Comment Metformin-related decreases in hepatic TNF-alpha mRNA concentrations are associated with a significant down-regulation of UCP-2 mRNA concentrations in liver.
Formal Description
Interaction-ID: 1344

drug/chemical compound


decreases_expression of



in liver
Drugbank entries Show/Hide entries for Metformin or TNF