General Information:

Id: 322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
BTO:0000007 HEK-293 cells (transfected)
Reference: Yu G et al.(2000) Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing Nature 407: 48-54 [PMID: 10993067]

Interaction Information:

Comment Missense mutations in a conserved hydrophilic domain of nicastrin increase amyloid-beta42 and amyloid-beta40 peptide secretion. Deletions in this domain inhibit amyloid-beta production.
Formal Description
Interaction-ID: 1273

gene/protein mutant


decreases_quantity of


Amyloid beta peptide

decreased gamma-secretase cleavage by deletion mutations of NCSTN;