General Information:

Id: 315 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
ob/ob mouse; lipodystrophic mouse (transgenic mouse expressing truncated SREBP-1c436)
BTO:0000759 liver
article
Reference: Shimomura I et al.(2000) Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice Mol. Cell 6: 77-86 [PMID: 10949029]

Interaction Information:

Comment Insulin resistance in the liver leads to overproduction of glucose, because the normal action of insulin in repressing the mRNAs of gluconeogenetic enzymes is reduced.
Formal Description
Interaction-ID: 1247

complex/PPI

Insulin

decreases_activity of

process

gluconeogenesis