General Information:

Id: 3,141 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Zucker rat, obese (OZR) or lean (LZR)
Reference: Muller H et al.(2007) Angiotensin II stimulates the reactivity of the pituitary-adrenal axis in leptin-resistant Zucker rats, thereby influencing the glucose utilization. Am. J. Physiol. Endocrinol. Metab. 293: E802-E810 [PMID: 17595220]

Interaction Information:

Comment The pituitary-adrenal axis (PA axis) is synergistically activated by angiotensin II (ANG II) and leptin resistance and that hyperreactivity is as a result paralleled by an impaired glucose utilization.
Formal Description
Interaction-ID: 28936


Angiotensin II

decreases_activity of


glucose utilization

via a hyperreactive PA-axis