General Information:

Id: 309 (click here to show other Interactions for entry)
Diseases: Neurological
Homo sapiens
BTO:0000793 SH-SY5Y cell
Reference: Smith WW et al.(2006) Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nat. Neurosci. 9: 1231-1233 [PMID: 16980962]

Interaction Information:

Comment Alterations that reduce kinase activity of LRRK2-G2019S mutant reduce neuronal toxicity.
Formal Description
Interaction-ID: 1223

gene/protein mutant


increases_activity of


neuron death