General Information:

Id: 2,814 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Metabolic syndrome
Reference: Braun S et al.(2011) The link between the metabolic syndrome and cancer Int. J. Biol. Sci. 7: 1003-1015 [PMID: 21912508]

Interaction Information:

Comment The mitogen-activated protein kinase (MAPK) pathway can also be activated by IGF-1R activation. In this pathway IGF-1R activates the adaptor proteins, Shc and Grb2, leading to activation of Ras, Raf, MEK1/2, and ERK1/2, which results in cell proliferation.
Formal Description
Interaction-ID: 26036



increases_activity of