General Information:

Id: 2,696 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
article
Reference: Emanuelli B et al.(2008) Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc. Natl. Acad. Sci. U.S.A. 105: 3545-3550 [PMID: 18296638]

Interaction Information:

Comment Overexpression of MKP-4 in the liver of ob/ob mice decreased ERK and JNK phosphorylation, leading to a reduction in fed and fasted glycemia, improved glucose intolerance, decreased expression of gluconeogenic and lipogenic genes, and reduced hepatic steatosis.
Formal Description
Interaction-ID: 25232

gene/protein

DUSP9

decreases_activity of

process

gluconeogenesis