General Information:

Id: 268 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
Reference: Ko HS et al.(2009) CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc. Natl. Acad. Sci. U.S.A. 106: 2897-2902 [PMID: 19196961]

Interaction Information:

Comment Treatment with 17AAG, a HSP90 inhibitor, significantly protected against G2019S- and R1441C-LRRK2 mutant-induced cell death.
Formal Description
Interaction-ID: 3751

drug/chemical compound


decreases_activity of


neuron death

induced by LRRK2 mutants