General Information:

Id: 268 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
Reference: Ko HS et al.(2009) CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc. Natl. Acad. Sci. U.S.A. 106: 2897-2902 [PMID: 19196961]

Interaction Information:

Comment In contrast to LRRK2-WT, the R1441C and G2019S mutants of LRRK2 cause significant cell toxicity.
Formal Description
Interaction-ID: 1100

gene/protein mutant


increases_activity of


neuron death