General Information:

Id: 2,609 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0000759 liver
article
Reference: Zhang EE et al.(2010) Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat. Med. 16: 1152-1156 [PMID: 20852621]

Interaction Information:

Comment Cry1 expression was elevated during the night-day transition, when it reduced fasting gluconeogenic gene expression by blocking glucagon-mediated increases in intracellular cAMP concentrations and in the protein kinase A-mediated phosphorylation of Creb.
Formal Description
Interaction-ID: 24920

gene/protein

CRY1

decreases_activity of

process

gluconeogenesis

by blocking glucagon-mediated increases in intracellular cAMP concentrations and in the protein kinase A-mediated phosphorylation of Creb