General Information:

Id: 2,503 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: El Muayed M et al.(2010) Acute cytokine-mediated downregulation of the zinc transporter ZnT8 alters pancreatic beta-cell function. J. Endocrinol. 206: 159-169 [PMID: 20508080]

Interaction Information:

Comment ZnT8 knockdown in murine islets led to reduced glucose stimulated insulin secretion without altering the total cellular insulin content or cell viability at normal or supraphysiological Zn concentrations. The results suggest that an acute decrease in ZnT8 levels impairs beta-cell function and Zn homeostasis, and may contribute to inflammatory cytokine-induced alterations in beta-cell function.
Formal Description
Interaction-ID: 23323



affects_activity of

in pancreas, in pancreatic beta cells