General Information:

Id: 2,501 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
BTO:0003317 INS-1E cell
Reference: Chimienti F et al.(2006) In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J. Cell. Sci. 119: 4199-4206 [PMID: 16984975]

Interaction Information:

Comment ZnT-8 overexpression stimulated zinc accumulation and increased total intracellular zinc in insulin-secreting INS-1E cells. Furthermore, ZnT-8-overexpressing cells display enhanced glucose-stimulated insulin secretion compared with control cells, only for a high glucose challenge. The data strongly suggest that the zinc transporter ZnT-8 is a key protein for both zinc accumulation and regulation of insulin secretion in pancreatic beta cells.
Formal Description
Interaction-ID: 23298



affects_activity of

in pancreas, in pancreatic beta cells; after glucose stimulation