General Information:

Id: 2,469 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Homo sapiens
Reference: Saxena R et al.(2010) Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge Nat. Genet. 2: 142-148 [PMID: 20081857]

Interaction Information:

Comment A meta-analysis of nine genome-wide association studies identified variants at the GIPR locus associated with 2-h glucose level (rs10423928). The GIPR A-allele carriers also showed decreased insulin secretion and diminished incretin effect . The analysis also identified variants at ADCY5 (rs2877716), VPS13C (rs17271305), GCKR (rs1260326) and TCF7L2 (rs7903146) associated with 2-h glucose. Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies.
Formal Description
Interaction-ID: 72842



increases_activity of

in pancreas, in pancreatic islets; the effective allele is A