General Information:

Id: 2,276 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
C57BL/6J (B6J) mouse, C57BL/6N (B6N) mouse
Reference: Wong N et al.(2010) The deletion variant of nicotinamide nucleotide transhydrogenase (Nnt) does not affect insulin secretion or glucose tolerance. Endocrinology 151: 96-102 [PMID: 19906813]

Interaction Information:

Comment The C57BL/6J (B6J) strain is the most widely used mouse strain in metabolic research. B6J mice produce a truncated form of nicotinamide nucleotide transhydrogenase (NNT), an enzyme that pumps protons across the inner mitochondrial membrane. It has been proposed that this results in B6J mice having reduced insulin secretion and glucose intolerance compared with other strains of mice (e.g. C3H/HeH and DBA/2) that have a full-length NNT. C57BL/6N (B6N) mice have wild-type Nnt. Nnt expression and activity levels as well as in vivo insulin secretion and glucose tolerance were compared between these mice and B6J. Body weights and specific fat-pad depot masses were alike and Nnt expression and activity levels were similar between B6N and B6J mice. Glucose-mediated insulin secretion and insulin sensitivity were comparable between the two groups of mice, as were plasma glucose and insulin levels during the oral glucose tolerance test. The presence of a truncated Nnt did not affect insulin secretion or glucose tolerance on the C57BL/6 background.
Formal Description
Interaction-ID: 19430

gene/protein mutant


NOT affects_activity of

in pancreas