General Information:

Id: 2,273 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
ENU-induced point mutations in Nnt N68K and G745D
Reference: Freeman H et al.(2006) Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metab. 3: 35-45 [PMID: 16399503]

Interaction Information:

Comment Two ENU-induced point mutations in Nnt (N68K, G745D) were identified. Nnt mutant mice were glucose intolerant and secreted less insulin during a glucose tolerance test. Isolated islets showed impaired insulin secretion in response to glucose, but not to tolbutamide, and glucose failed to enhance ATP levels.
Formal Description
Interaction-ID: 19415

gene/protein mutant


affects_activity of

in pancreas; in response to glucose