General Information:

Id: 2,272 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
BTO:0002284 MIN-6 cell
Reference: Freeman H et al.(2006) Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion. Cell Metab. 3: 35-45 [PMID: 16399503]

Interaction Information:

Comment Nicotinamide nucleotide transhydrogenase (Nnt), is a nuclear-encoded mitochondrial protein thought to be involved in free radical detoxification, as a candidate gene. To investigate its functional role, we used siRNA to knock down Nnt in insulin-secreting MIN6 cells. This produced a dramatic reduction in insulin secretion and the rise in [Ca2+]i evoked by glucose, but not tolbutamide.
Formal Description
Interaction-ID: 19406



affects_activity of

in pancreas
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