General Information:

Id: 2,266 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
SPP1 -/- mouse (OPN-/-)
article
Reference: Kiefer FW et al.(2011) Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia 54: 2132-2142 [PMID: 21562757]

Interaction Information:

Comment OPN deficiency markedly improved hepatic insulin signalling as shown by enhanced insulin receptor substrate-2 phosphorylation and prevented upregulation of the major hepatic transcription factor Forkhead box O1 and its gluconeogenic target genes G6pc and Mttp.
Formal Description
Interaction-ID: 19342

gene/protein

SPP1

affects_activity of

process

gluconeogenesis

in liver