General Information:

Id: 2,119 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Oelze M et al.(2006) Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertension 48: 677-684 [PMID: 16940222]

Interaction Information:

Comment Ang II treatment upregulated the expression of p67phox and Rac1 in aortic membrane fractions and in heart membranes, all of which was normalized by in vivo nebivolol treatment. In addition, there were significant increases in the expression of Nox1 in heart membranes that were decreased by treatment with nebivolol. Significant increases in Nox2 (gp91phox), p47phox, and p22phox mRNA were found in aortic and heart tissue ranging from 2- to 4-fold, all of which were almost normalized by nebivolol but not metoprolol cotreatment in vivo.
Formal Description
Interaction-ID: 17359


Angiotensin II

increases_expression of



in membranes, in aorta, in cardiac muscle