General Information:

Id: 2,072 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
ApoE4 mouse
Reference: Shenk JC et al.(2009) The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimers disease J. Neurol. Sci. 283: 199-206 [PMID: 19342064]

Interaction Information:

Comment ApoE4 reduces CBF gradually to create brain hypoperfusion when compared to WT and the differences in CBF are greatest as animals age from 6 weeks to 12 months.
Formal Description
Interaction-ID: 16717

gene/protein mutant

APOE (isoform E4)

increases_activity of


brain hypoperfusion

in ApoE4 6-month and 12-month mice; compared to WT mouse