General Information:

Id: 202 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0000938 neuron
Reference: Taoufik E et al.(2008) TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury Proc. Natl. Acad. Sci. U.S.A. 105: 6185-6190 [PMID: 18413601]

Interaction Information:

Comment Erythropoietin (EPO) and VEGF (VEGFA) protect cortical neurons in diverse models of neuronal death. Experiments with TNFR1 KO mice showed, that TNFR1 activity is required for this neuroprotective process.
Formal Description
Interaction-ID: 802



decreases_activity of


neuron death