General Information:

Id: 2,009 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Ren-2 rat: transgenic hypertensive TG(mREN-2)27 rat
Reference: Blendea MC et al.(2005) Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression Am. J. Physiol. Endocrinol. Metab. 288: E353-E359 [PMID: 15494608]

Interaction Information:

Comment Many tissues possess intrinsic angiotensinogen and angiotensin-converting enzyme activity, and thus are able to express a tissue renin-angiotensin system (RAS). A rodent model for tissue overexpression of RAS is the TG(mREN-2)27 (Ren-2) rat, a transgenic animal that harbors the mouse Ren-2 renin gene. This rodent model develops severe hypertension as a consequence of increases in the local RAS that culminates in elevated tissue ANG II levels.
Formal Description
Interaction-ID: 15950



increases_quantity of


Angiotensin II

in Ren-2 rats
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