General Information:

Id: 1,989 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Myocardial infarction - [OMIM]
Nephropathy, diabetic
Neuropathy, diabetic
Retinopathy, diabetic
Stroke, ischemic - [OMIM]
Reference: Lardizabal JA and Deedwania PC(2010) The role of renin-angiotensin agents in altering the natural history of type 2 diabetes mellitus Curr Cardiol Rep 12: 464-471 [PMID: 20809236]

Interaction Information:

Comment AT II, a powerful vasoconstrictor and growth factor, can interfere with the normal insulin signaling pathway through serine phosphorylation of specific insulin receptors in the muscle cell, contributing to the insulin resistance observed in essential hypertension.
Formal Description
Interaction-ID: 15671


Angiotensin II

increases_activity of


Insulin resistance