General Information:

Id: 1,978 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Velloso LA et al.(1996) Cross-talk between the insulin and angiotensin signaling systems Proc. Natl. Acad. Sci. U.S.A. 93 [PMID: 8901609]

Interaction Information:

Comment Following AII injection there was a dose-dependent inhibition of PI 3-kinase activity associated with IRS-1 and IRS-2, with maximal decreases of 55% and 60% below basal values after injection of as little as 200 pmol of AII.
Formal Description
Interaction-ID: 15525


Angiotensin II

decreases_activity of


Phosphatidylinositol 3-kinase

in cardiac muscle