General Information:

Id: 1,978 (click here to show other Interactions for entry)
Diseases: Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
Reference: Velloso LA et al.(1996) Cross-talk between the insulin and angiotensin signaling systems Proc. Natl. Acad. Sci. U.S.A. 93 [PMID: 8901609]

Interaction Information:

Comment Following injection of insulin and/or angiotensin II (All) into rats, the authors find that there is a rapid tyrosine phosphorylation of the major insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) in the heart.
Formal Description
Interaction-ID: 15518


Angiotensin II

increases_phosphorylation of



in cardiac muscle; at Tyr residues
Drugbank entries Show/Hide entries for IRS1