General Information:

Id: 1,655 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
Reference: El-Haschimi K et al.(2000) Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity J. Clin. Invest. 105: 1827-1832 [PMID: 10862798]

Interaction Information:

Comment In mice fed the low-fat diet, leptin activated STAT3 (signal transducer and activator of transcription) signaling when administered via the intraperitoneal (ip) or the intracerebroventricular (icv) route, with the half-maximal dose being 30-fold less when given by the icv route.
Formal Description
Interaction-ID: 12128



increases_activity of


STAT3 signaling pathway

after low-fat diet