General Information:

Id: 1,627 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Hill JW et al.(2008) Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice J. Clin. Invest. 118: 1796-1805 [PMID: 18382766]

Interaction Information:

Comment A PI3K-dependent mechanism is required for the leptin-induced activation of proopiomelanocortin (POMC) neurons, which are located in the arcuate nucleus (ARC) of the hypothalamus.
Formal Description
Interaction-ID: 11917



increases_activity of

tissue/cell line

POMC-expressing neuron

in the arcuate nucleus of the hypothalamus; via PI3K