General Information:

Id: 1,347 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Obesity - [OMIM]
Mus musculus
Reference: Ouchi N et al.(2010) Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 329: 454-457 [PMID: 20558665]

Interaction Information:

Comment To analyze the downstream signaling pathways affected by Sfrp5 deficiency, the authors assessed whether the canonical or noncanonical Wnt signaling pathways were activated in epididymal adipose tissues of Sfrp5-/- and WT mice fed a high fat high sucrose diet. No differences were detected in transcript expression of cyclin D1 or WISP-2, indicators of canonical Wnt signaling, between Sfrp5-/- and WT mice. In contrast, phosphorylation of c-Jun N-terminal kinase (JNK), a downstream target of the noncanonical Wnt signaling, was elevated in white adipose tissue in Sfrp5-/- mice. Also, the phosphorylation of c-Jun, a downstream substrate of JNK, was elevated in Sfrp5-/- mice compared with WT mice.
Formal Description
Interaction-ID: 9202



NOT affects_activity of

in epididymal adipose tissues; after high-fat high-sucrose diet