General Information:

Id: 1,311 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
ob/ob mouse
article
Reference: Ozcan U et al.(2006) Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 5790: 1137-1140 [PMID: 16931765]

Interaction Information:

Comment The authors found that administration of both PBA and TUDCA significantly suppressed hepatic glucose production (HGP) at baseline and during the clamp studies.
Formal Description
Interaction-ID: 8988

drug/chemical compound

Sodium phenylbutyrate

decreases_activity of

process

gluconeogenesis

in liver
Comment The authors found that administration of both PBA and TUDCA significantly suppressed hepatic glucose production (HGP) at baseline and during the clamp studies.
Formal Description
Interaction-ID: 8989

drug/chemical compound

Tauroursodeoxycholic acid

decreases_activity of

process

gluconeogenesis

in liver