General Information:

Id: 122 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Grimes CA and Jope RS(2001) The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling Prog. Neurobiol. 65: 391-426 [PMID: 11527574]

Interaction Information:

Comment GSK3B is regulated by Wnt signaling. In the absence of Wnt, GSK3B is complexed with Axin and APC and phosphorylates beta-catenin, targeting it for degradation.
Formal Description
Interaction-ID: 463

affects_activity of



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Comment Lithium activates the Wnt signaling pathway.
Formal Description
Interaction-ID: 570

drug/chemical compound


increases_activity of

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