General Information:

Id: 1,217 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Riant E et al.(2009) Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice Endocrinology 150: 2109-2117 [PMID: 19164473]

Interaction Information:

Comment Although E2 treatment did not influence the level of cytokines after 1 month of high-fat feeding, it significantly increased the plasma levels of IL-6 (16.6-fold), TNF-alpha (16.5-fold), and IL-1beta (2.8-fold) in mice fed with this diet for 3 months.
Formal Description
Interaction-ID: 8201

drug/chemical compound


increases_quantity of



in blood; after 3 months of high-fat diet
Drugbank entries Show/Hide entries for Estradiol or IL6