General Information:

Id: 1,203 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
Reference: Weisberg SP et al.(2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding J. Clin. Invest. 116: 115-124 [PMID: 16341265]

Interaction Information:

Comment Consistent with the gene expression data, there were no CCR2-dependent alterations in the circulating concentration of IL-6. In contrast, lower circulating concentrations of PAI-1 in lean and obese Ccr2-/- mice were detected when compared with weightmatched Ccr2+/+ mice. These data reveal that CCR2 modulates circulating PAI-1 by a mechanism that is not primarily dependent upon adipose tissue expression or the development of obesity.
Formal Description
Interaction-ID: 8073



NOT affects_quantity of



in blood
Drugbank entries Show/Hide entries for IL6