General Information:

Id: 1,179
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mus musculus
male
article
Reference: Becerril S et al.(2010) Deletion of inducible nitric-oxide synthase in leptin-deficient mice improves brown adipose tissue function PLoS ONE 5 [PMID: 20532036]

Interaction Information:

Comment The deletion of the iNOS gene in ob/ob mice dramatically reduced the size of brown adipocytes.
Formal Description
Interaction-ID: 7801

gene/protein

NOS2

affects_quantity of

tissue/cell line

brown adipose tissue

in ob/ob mice
Drugbank entries Show/Hide entries for NOS2
Comment The gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Formal Description
Interaction-ID: 7802

organism model

ob/ob mouse

decreases_expression of

gene/protein

UCP1

Comment The gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Formal Description
Interaction-ID: 7804

gene/protein

NOS2

affects_expression of

gene/protein

UCP1

Drugbank entries Show/Hide entries for NOS2
Comment The gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Formal Description
Interaction-ID: 7806

organism model

ob/ob mouse

decreases_expression of

gene/protein

UCP3

Comment The gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Formal Description
Interaction-ID: 7807

gene/protein

NOS2

affects_expression of

gene/protein

UCP3

Drugbank entries Show/Hide entries for NOS2
Comment DBKO mice simultaneously lacking the ob and iNOS genes showed a statistically significant increase in Ucp-1 and Ucp-3 transcripts and proteins compared to ob/ob mice.
Formal Description
Interaction-ID: 7808

organism model

DBKO mouse

increases_expression of

gene/protein

UCP1

Comment iNOS deficiency results in decreased body weight and reduced white fat pads, not only in wild type but also in leptin-deficient obese mice.
Formal Description
Interaction-ID: 7813

gene/protein

NOS2

affects_activity of

disease

Obesity

Drugbank entries Show/Hide entries for NOS2
Comment iNOS deletion enhanced the expression of mitochondria-related proteins, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (Pgc-1alpha), sirtuin-1 (Sirt-1) and sirtuin-3 (Sirt-3). Accordingly, mitochondrial uncoupling proteins 1 and 3 (Ucp-1 and Ucp-3) were upregulated in brown adipose tissue (BAT) of DBKO mice as compared to ob/ob rodents.
Formal Description
Interaction-ID: 7814

gene/protein

NOS2

affects_expression of

gene/protein

PPARGC1A

Drugbank entries Show/Hide entries for NOS2
Comment Ablation of iNOS improved the energy balance of ob/ob mice by decreasing food efficiency through an increase in thermogenesis.
Formal Description
Interaction-ID: 7815

gene/protein

NOS2

affects_activity of

in ob/ob mice
Drugbank entries Show/Hide entries for NOS2
Comment iNOS deletion enhanced the expression of mitochondria-related proteins, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (Pgc-1alpha), sirtuin-1 (Sirt-1) and sirtuin-3 (Sirt-3). Accordingly, mitochondrial uncoupling proteins 1 and 3 (Ucp-1 and Ucp-3) were upregulated in brown adipose tissue (BAT) of DBKO mice as compared to ob/ob rodents.
Formal Description
Interaction-ID: 13352

gene/protein

NOS2

affects_expression of

gene/protein

SIRT1

Drugbank entries Show/Hide entries for NOS2
Comment iNOS deletion enhanced the expression of mitochondria-related proteins, such as peroxisome proliferator-activated receptor gamma coactivator-1 alpha (Pgc-1alpha), sirtuin-1 (Sirt-1) and sirtuin-3 (Sirt-3). Accordingly, mitochondrial uncoupling proteins 1 and 3 (Ucp-1 and Ucp-3) were upregulated in brown adipose tissue (BAT) of DBKO mice as compared to ob/ob rodents.
Formal Description
Interaction-ID: 13353

gene/protein

NOS2

affects_expression of

gene/protein

SIRT3

Drugbank entries Show/Hide entries for NOS2 or SIRT3
Comment Ablation of iNOS improved the energy balance of ob/ob mice by decreasing food efficiency through an increase in thermogenesis.
Formal Description
Interaction-ID: 13354

gene/protein

NOS2

affects_activity of

in ob/ob mice
Drugbank entries Show/Hide entries for NOS2
Comment DBKO mice simultaneously lacking the ob and iNOS genes showed a statistically significant increase in Ucp-1 and Ucp-3 transcripts and proteins compared to ob/ob mice.
Formal Description
Interaction-ID: 46079

organism model

DBKO mouse

increases_expression of

gene/protein

UCP3