General Information:

Id: 1,162 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
LIKK mouse: mouse selectively expressing constitutively active IKK-beta in hepatocytes; LISR mouse: mouse selectively expressing the I-kappa-B-alpha superrepressor in liver
Reference: Cai D et al.(2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat Med 11: 183-190 [PMID: 15685173]

Interaction Information:

Comment Consistent again with a potential role for IL-6 in the development of obesity- and diet-induced insulin resistance, NF-kappaB inhibition in LISR mice was accompanied by a substantial 64% decrease in Il6 mRNA expression.
Formal Description
Interaction-ID: 7725



affects_expression of



in LISR mice
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