General Information:

Id: 1,107 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Candore G et al.(2010) Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications Rejuvenation Res 13: 301-313 [PMID: 20462385]

Interaction Information:

Comment Senile plaques (characterized by the accumulation of proteinsin the form of beta-pleated sheet fibrils, which are composed mainly of a 42-amino-acid peptide known as beta-amyloid (Ab),and neurofibrillary tangles, mainly composed by a cytoskeletal hyperphosphorylated protein tau) in AD brains are associated with reactive astrocytes and activated microglial cells, which overexpress cytokines and acute-phase proteins.
Formal Description
Interaction-ID: 145268

affects_activity of

in AD brain