General Information:

Id: 1,092 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: de Luca C and Olefsky JM(2008) Inflammation and insulin resistance FEBS Lett. 582: 97-105 [PMID: 18053812]

Interaction Information:

Comment Macrophages are also capable of undergoing a phenotypic switch from an M1 state, which was defined as the 'classically activated' pro-inflammatory macrophage, to the M2 state or the 'alternatively activated' non-inflammatory cell. The M2 classification involves cells that express arginase and the anti-inflammatory cytokine Il-10 and have a high capacity to repair damaged tissue. M1 cells express inflammatory cytokines and the cell surface marker Cd11c. Adipose tissue from obese mice contains proportionately more M1 macrophages, whereas, lean adipose tissue contains more M2 macrophages, and increased M1 content positively correlates with inflammation, macrophage infiltration and insulin resistance.
Formal Description
Interaction-ID: 7302

tissue/cell line

M1 macrophage

increases_activity of