General Information:

Id: 1,086 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0000099 astrocyte
Reference: Waak J et al.(2009) Regulation of astrocyte inflammatory responses by the Parkinsons disease-associated gene DJ-1 FASEB J. 23: 2478-2489 [PMID: 19276172]

Interaction Information:

Comment LPS stimulated transient phosphorylation of the stress-activated protein kinases JNK and p38MAPK. Phosphorylation was significantly stronger in Dj-1-/- astrocyte cultures. Thus, the p38MAPK pathway may be specifically involved in the DJ-1-regulated astrocyte inflammatory responses.
Formal Description
Interaction-ID: 8543

increases_activity of