General Information:

Id: 1,032
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Zabolotny JM et al.(2008) Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J. Biol. Chem. 283 [PMID: 18281274]

Interaction Information:

Comment To determine whether the increased TNF-alpha expression observed in adipose tissue of mice with diet-induced obesity could mediate PTP1B overexpression, differentiated 3T3-L1 adipocytes and H-4-II-E hepatoma cells, as well as HeLa cells were treated with murine TNF-alpha and the expression of PTP1B protein was measured. TNF-alpha treatment increased PTP1B protein expression 3- to 5-fold in 3T3-L1 adipocyte in a dose- and time-dependent manner. Similarly, TNF-alpha treatment increased PTP1B protein levels by 2-fold in H-4-II-E hepatoma cells. TNF-alpha also increased PTP1B protein levels by 2- to 3-fold in HeLa cells, in a dose- and timedependent manner. Similar results were observed in serumstarved and unstarved HeLa cells and in HeLa cells treated with murine and human TNF-alpha.
Formal Description
Interaction-ID: 6454



increases_expression of



in differentiated 3T3-L1 adipocytes, in H-4-II-E hepatoma cells, in HeLa cells
Drugbank entries Show/Hide entries for TNF or PTPN1