General Information:

Id: 6,618 (click here to show other Interactions for entry)
Diseases: Q fever
pathogen-host system
Coxiella burnetii/mammalia
primary mouse macrophages, coinfected with C. burnetii strain RSA 493 phase II and L. pneumophila
article
Reference: Cunha LD et al.(2015) Inhibition of inflammasome activation by Coxiella burnetii type IV secretion system effector IcaA Nat Commun 6: 10205 [PMID: 26687278]

Interaction Information:

Comment C. burnetii inhibits the caspase-11-mediated non-canonical activation of the NLRP3 inflammasome induced by L. pneumophila, as shown in bone marrow-derived macrophages (BMDMs),infected with C. burnetii for 24 h and further infected with wild-type L. pneumophila.
Formal Description
Interaction-ID: 63072

process

Coxiella burnetii infection

decreases_activity of

cellular component

NLRP3 inflammasome complex

in macrophages, induced by L. pneumophila