General Information:

Id: 6,556
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
BTO:0001412 U-937 cell, induced and differentiated into macrophages with phorbol 12-myristate 13-acetate (PMA)
article
Reference: Chai W et al.(2014) Pseudomonas pyocyanin stimulates IL-8 expression through MAPK and NF-kappaB pathways in differentiated U937 cells BMC Microbiol. 14: 26 [PMID: 24499192]

Interaction Information:

Comment P. aeruginosa pyocyanin (PCN) induces IL-8 (CXCL8) secretion and mRNA expression in PMA-differentiated U937 cells in a concentration- and time- dependent manner.
Formal Description
Interaction-ID: 62300

drug/chemical compound

Pyocyanine

increases_expression of

gene/protein

CXCL8

in PMA-differentiated U937 cells
Comment P. aeruginosa pyocyanin (PCN) induces IL-8 (CXCL8) secretion and mRNA expression in PMA-differentiated U937 cells in a concentration- and time- dependent manner.
Formal Description
Interaction-ID: 62327

drug/chemical compound

Pyocyanine

increases_quantity of

gene/protein

CXCL8

in PMA-differentiated U937 cells
Comment P. aeruginosa pyocyanin (PCN) stimulated U937 cells to activate NF-kappaB signaling pathway. PCN induces degradation of I-kappaB-alpha and subsequent translocation of NF-kappaB to the nucleus.
Formal Description
Interaction-ID: 62331

drug/chemical compound

Pyocyanine

increases_activity of

in PMA-differentiated U937 cells