General Information:

Id: 6,554 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human lung fibroblast cell line (IMR-90), incubated with Pseudomonas aeruginosa produced elastase (PE) with
article
Reference: Azghani AO et al.(2014) Mechanism of fibroblast inflammatory responses to Pseudomonas aeruginosa elastase Microbiology (Reading 160: 547-555 [PMID: 24385476]

Interaction Information:

Comment P. aeruginosa produced elastase (PE) activates ERK via EGFR. PE stimulates ERK1/2 phosphorylation via the EGFR/MEK pathway and that the activation process requires an enzymically active PE.
Formal Description
Interaction-ID: 62294

gene/protein

lasB

increases_activity of

gene/protein

EGFR

Drugbank entries Show/Hide entries for lasB or EGFR