General Information:

Id: 6,554 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
human lung fibroblast cell line (IMR-90), incubated with Pseudomonas aeruginosa produced elastase (PE) with
article
Reference: Azghani AO et al.(2014) Mechanism of fibroblast inflammatory responses to Pseudomonas aeruginosa elastase Microbiology (Reading 160: 547-555 [PMID: 24385476]

Interaction Information:

Comment P. aeruginosa produced elastase (PE) increases the level of phosphorylated ERK1/2 kinases in human lung fibroblasts. PE activates ERK1/2 in a concentration- and timedependent fashion.
Formal Description
Interaction-ID: 62284

gene/protein

lasB

increases_activity of

Drugbank entries Show/Hide entries for lasB
Comment P. aeruginosa produced elastase (PE) increases the level of phosphorylated ERK1/2 kinases in human lung fibroblasts. PE activates ERK1/2 in a concentration- and timedependent fashion.
Formal Description
Interaction-ID: 62291

gene/protein

lasB

increases_activity of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for lasB or MAPK1
Comment P. aeruginosa produced elastase (PE) increases the level of phosphorylated ERK1/2 kinases in human lung fibroblasts. PE activates ERK1/2 in a concentration- and timedependent fashion.
Formal Description
Interaction-ID: 62292

gene/protein

lasB

increases_phosphorylation of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for lasB or MAPK3
Comment P. aeruginosa produced elastase (PE) increases the level of phosphorylated ERK1/2 kinases in human lung fibroblasts. PE activates ERK1/2 in a concentration- and timedependent fashion.
Formal Description
Interaction-ID: 62293

gene/protein

lasB

increases_phosphorylation of

gene/protein

MAPK1

Drugbank entries Show/Hide entries for lasB or MAPK1
Comment P. aeruginosa produced elastase (PE) activates ERK via EGFR. PE stimulates ERK1/2 phosphorylation via the EGFR/MEK pathway and that the activation process requires an enzymically active PE.
Formal Description
Interaction-ID: 62294

gene/protein

lasB

increases_activity of

gene/protein

EGFR

Drugbank entries Show/Hide entries for lasB or EGFR
Comment P. aeruginosa produced elastase (PE) enhances IL-8 (CXCL8) gene expression in fibroblasts.
Formal Description
Interaction-ID: 62295

gene/protein

lasB

increases_expression of

gene/protein

CXCL8

Drugbank entries Show/Hide entries for lasB
Comment P. aeruginosa produced elastase (PE) increases IL-8 (CXCL8) protein production in fibroblasts.
Formal Description
Interaction-ID: 62296

gene/protein

lasB

increases_quantity of

gene/protein

CXCL8

Drugbank entries Show/Hide entries for lasB
Comment P. aeruginosa produced elastase (PE) treatment increases the activation of NF-kB in fibroblasts. PE-treated monolayers showed a significant increase in NF-kB nuclear translocation that was detectable by 10 min and was sustained for an hour.
Formal Description
Interaction-ID: 62297

gene/protein

lasB

increases_activity of

Drugbank entries Show/Hide entries for lasB
Comment Pseudomonas aeruginosa produced elastase (PE) increases the level of phosphorylated ERK1/2 kinases in human lung fibroblasts. PE activates ERK1/2 in a concentration- and timedependent fashion.
Formal Description
Interaction-ID: 62299

gene/protein

lasB

increases_activity of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for lasB or MAPK3