General Information:

Id: 6,463 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Ravichandran A et al.(2015) Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1 PLoS ONE 10 [PMID: 25894344]

Interaction Information:

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61849

gene/protein

morA

decreases_quantity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment MorA loss results in a substantial increase of elastase (LasB), the major protease secreted by T2SS, in the extracellular fraction. The elastolytic activity is also correspondingly high in the extracellular fraction in morA mutants.
Formal Description
Interaction-ID: 61882

gene/protein

morA

decreases_activity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB