General Information:

Id: 6,463
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
P. aeruginosa strain PAO1
article
Reference: Ravichandran A et al.(2015) Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1 PLoS ONE 10 [PMID: 25894344]

Interaction Information:

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61203

gene/protein

morA

decreases_quantity of

gene/protein

PA0572

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61839

gene/protein

morA

decreases_quantity of

gene/protein

paaP

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61844

gene/protein

morA

decreases_quantity of

gene/protein

aprA

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61846

gene/protein

morA

decreases_quantity of

gene/protein

cpbD

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61849

gene/protein

morA

decreases_quantity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61850

gene/protein

morA

decreases_quantity of

gene/protein

prpL

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61862

gene/protein

morA

decreases_quantity of

gene/protein

fliD

Comment MorA affects levels of extracellular proteins (PA0572, PA2939, AprA, CbpD ,LasB, PrpL, FliD, LasA) in P. aeruginosa PAO1. Strains lacking MorA had higher overall levels of extracellular proteins than WT in planktonic culture supernatants.
Formal Description
Interaction-ID: 61863

gene/protein

morA

decreases_quantity of

gene/protein

lasA

Comment MorA controls T2SS secretome levels via its c-di-GMP signaling domains.
Formal Description
Interaction-ID: 61875

gene/protein

morA

affects_activity of

process

T2SS (Xcp)

Comment The invasion efficiency of P. aeruginosa morA KO was at least two-fold higher compared to WT.
Formal Description
Interaction-ID: 61881

gene/protein

morA

decreases_activity of

process

P. aeruginosa infection, acute

as shown in infected lung fibroblast line MRC-5
Comment MorA loss results in a substantial increase of elastase (LasB), the major protease secreted by T2SS, in the extracellular fraction. The elastolytic activity is also correspondingly high in the extracellular fraction in morA mutants.
Formal Description
Interaction-ID: 61882

gene/protein

morA

decreases_activity of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment The effect of MorA on T2SS is consistent with its enzymatic function i.e. its ability to regulate c-di-GMP levels.
Formal Description
Interaction-ID: 61883

gene/protein

morA

affects_quantity of

drug/chemical compound

cdiGMP

Comment The effect of MorA on T2SS is consistent with its enzymatic function i.e. its ability to regulate c-di-GMP levels.
Formal Description
Interaction-ID: 61885

drug/chemical compound

cdiGMP

affects_activity of

process

T2SS (Xcp)