General Information:

Id: 6,402
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Confluent monolayers of MDCK epithelial cells, apically infected with P. aeruginosa strain PAK or PAO1
article
Reference: Tran CS et al.(2014) The Pseudomonas aeruginosa type III translocon is required for biofilm formation at the epithelial barrier PLoS Pathog. 10 [PMID: 25375398]

Interaction Information:

Comment The apical infection of confluent monolayers of MDCK epithelial cells with the P. aeruginosa strain PAK or PAO1 leads to the formation of aggregates that exhibit key characteristics of biofilms (eDNA, exopolysaccharides, increased resistance to antibiotics).
Formal Description
Interaction-ID: 60368

process

P. aeruginosa infection, acute

increases_activity of

as shown on MDCK epithelial cells
Comment The results in MDCK cells show that the T3SS translocon (popB/popD) is required for cell-associated aggregation, whereas the known T3SS effectors exoS, T, Y) are not required. In a murine model of acute pneumonia this has been confirmed.
Formal Description
Interaction-ID: 60369

complex/PPI

T3SS translocon complex

increases_activity of

as shown on MDCK epithelial cells and in a murine model of acute neumonia
Comment The results in MDCK cells show that the T3SS translocon (popB/popD) is required for cell-associated aggregation, whereas the known T3SS effectors exoS, T, Y) are not required. In a murine model of acute pneumonia this has been confirmed.
Formal Description
Interaction-ID: 60379

gene/protein

exoS

NOT affects_activity of

as shown on MDCK epithelial cells and in a murine model of acute neumonia
Comment The results in MDCK cells show that the T3SS translocon (popB/popD) is required for cell-associated aggregation, whereas the known T3SS effectors exoS, T, Y) are not required. In a murine model of acute pneumonia this has been confirmed.
Formal Description
Interaction-ID: 60380

gene/protein

exoT

NOT affects_activity of

as shown on MDCK epithelial cells and in a murine model of acute neumonia
Comment The results in MDCK cells show that the T3SS translocon (popB/popD) is required for cell-associated aggregation, whereas the known T3SS effectors exoS, T, Y) are not required. In a murine model of acute pneumonia this has been confirmed.
Formal Description
Interaction-ID: 60381

gene/protein

exoY

NOT affects_activity of

as shown on MDCK epithelial cells and in a murine model of acute neumonia