General Information:

Id: 5,271
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
P. aeruginosa strain PA7
article
Reference: Cadoret F et al.(2014) Txc, a new type II secretion system of Pseudomonas aeruginosa strain PA7, is regulated by the TtsS/TtsR two-component system and directs specific secretion of the CbpE chitin-binding protein J. Bacteriol. 196: 2376-2386 [PMID: 24748613]

Interaction Information:

Comment The TtsS (PSPA7_1420) sensor protein, located in the genomic island RGP69 of strain PA7, forms a two-component system with the upstream-encoded response regulator TtsR (PSPA7_1421), as analyzed in a E. coli two-hybrid (BACTH) method.
Formal Description
Interaction-ID: 51499

gene/protein

ttsS

interacts (colocalizes) with

gene/protein

ttsR

Comment The TtsS (PSPA7_1420) sensor and the TtsR (PSPA7_1421) response regulator positively regulate the expression of the downstream cbpE (PSPA7_1419) and txc T2SS (PSPA7_1417-PSPA7_1407) genes. The coregulation of the cbpE and txc genes by TtsS/TtsR supports a functional link between the two corresponding proteins, such as the secretion of CbpE by the Txc T2S.
Formal Description
Interaction-ID: 51500

gene/protein

ttsR

increases_expression of

gene/protein

cbpE

Comment The TtsS (PSPA7_1420) sensor and the TtsR (PSPA7_1421) response regulator positively regulate the expression of the downstream cbpE (PSPA7_1419) and txc T2SS (PSPA7_1417-PSPA7_1407) genes. The coregulation of the cbpE and txc genes by TtsS/TtsR supports a functional link between the two corresponding proteins, such as the secretion of CbpE by the Txc T2S.
Formal Description
Interaction-ID: 51501

gene/protein

ttsR

increases_expression of

complex/PPI

T2SS (Txc)-associated complexes

Comment CbpE (PSPA7_1419) is secreted in strain PA7 by the Txc T2SS (type II secretion system). The analysis of the extracellular fraction showed that CbpE is secreted by strain PA7 only when TtsS(C-terminal cytoplasmic domain) or TtsR(C-terminal domain) is overproduced.
Formal Description
Interaction-ID: 51502

complex/PPI

T2SS (Txc)-associated complexes

increases_activity of

process

T2SS (Txc)

Comment CbpE (PSPA7_1419) is secreted in strain PA7 by the Txc T2SS (type II secretion system). The analysis of the extracellular fraction showed that CbpE is secreted by strain PA7 only when TtsS(C-terminal cytoplasmic domain) or TtsR(C-terminal domain) is overproduced.
Formal Description
Interaction-ID: 51503

process

T2SS (Txc)

increases_transport of

gene/protein

cbpE

Comment The experiments show that there is coexistence of three functional T2SSs (type II secretion systems), T2SS (Xcp), T2SS (Hxc) and T2SS (Txc) in the same P. aeruginosa strain. The two Xcp substrates, CbpD and LasB, are secreted into the extracellular medium by WT and Txc-deficient PA7 strains.
Formal Description
Interaction-ID: 51516

process

T2SS (Txc)

increases_transport of

gene/protein

cpbD

Comment The experiments show that there is coexistence of three functional T2SSs (type II secretion systems), T2SS (Xcp), T2SS (Hxc) and T2SS (Txc) in the same P. aeruginosa strain. The two Xcp substrates, CbpD and LasB, are secreted into the extracellular medium by WT and Txc-deficient PA7 strains.
Formal Description
Interaction-ID: 51520

process

T2SS (Txc)

increases_transport of

gene/protein

lasB

Drugbank entries Show/Hide entries for lasB
Comment The experiments show that there is coexistence of three functional T2SSs (type II secretion systems), T2SS (Xcp), T2SS (Hxc) and T2SS (Txc) in the same P. aeruginosa strain. The Hxc T2SS substrate LapC is secreted into the extracellular medium by WT and Txc-deficient PA7 strains grown under conditions of phosphate starvation, conditions required for hxc induction.
Formal Description
Interaction-ID: 51522

process

T2SS (Txc)

increases_transport of

gene/protein

lapC

under conditions of phosphate starvation
Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51528

gene/protein

txcP

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51537

gene/protein

txcQ

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51538

gene/protein

txcR

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51539

gene/protein

txcS

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51540

gene/protein

txcT

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51541

gene/protein

txcU

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51542

gene/protein

txcV

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51544

gene/protein

txcW

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51545

gene/protein

txcX

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51546

gene/protein

txcY

is_part_of

complex/PPI

T2SS (Txc)-associated complexes

Comment The authors identified a third complete T2SS (type II secretion system) in P. aeruginosa strain PA7. The 11 T2SS “core” genes txcP to txcZ (PSPA7_1417 to PSPA7_1407) present in the genomic island RGP69 are arranged unidirectionally and may constitute a single operon.
Formal Description
Interaction-ID: 51547

gene/protein

txcZ

is_part_of

complex/PPI

T2SS (Txc)-associated complexes