General Information:

Id: 5,267 (click here to show other Interactions for entry)
Diseases: Pseudomonas aeruginosa diseases
pathogen-host system
Pseudomonas aeruginosa/mammalia
Rat pulmonary microvascular endothelial cells (PMVECs), infected with P. aeruginosa strain 388
article
Reference: Balczon R et al.(2013) Pseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells PLoS ONE 8 [PMID: 24023939]

Interaction Information:

Comment P. aeruginosa toxin ExoY, which is an adenylyl and guanylyl cyclase molecule lacking membrane anchoring domains, decreased levels of microtubules in PMVECs and induced barrier breakdown by generating cyclic nucleotides (cAMP and/or cGMP) within a cytosolic domain.
Formal Description
Interaction-ID: 51372

gene/protein

exoY

decreases_activity of